Set recreate = true in tox.ini
diff --git a/tox.ini b/tox.ini
index 3a31558d814..6d9814192c0 100644
--- a/tox.ini
+++ b/tox.ini
@@ -67,6 +67,9 @@ passenv =
 commands =
     {[base]install_and_test} {[base]all_packages}
     python tests/lock_test.py
+# We always recreate the virtual environment to avoid problems like
+# https://github.com/certbot/certbot/issues/7745.
+recreate = true
 setenv =
     PYTEST_ADDOPTS = {env:PYTEST_ADDOPTS:--numprocesses auto}
     PYTHONHASHSEED = 0

Fixes https://github.com/certbot/certbot/issues/7745.